Response to induction chemotherapy in sinonasal malignancies: A single‐institutional experience

Abstract

AbstractBackgroundSinonasal malignancy (SNM) is a heterogeneous group of diseases for which induction chemotherapy (IC) may reduce tumor burden. The purpose of this study was to characterize the response to IC in SNM as a prognostic factor through its effect on survival.MethodsRetrospective cohort of patients undergoing IC for SNM between 2010 and 2019 at our quaternary referral center.ResultsForty‐two patients with advanced SNM were included in the analysis. Patients with a favorable response to IC had higher survival rates than those who had an unfavorable response (5‐year OS: 66.8% vs. 9.7%; p < 0.001; PFS: 56.8% vs. 0%; p < 0.001).ConclusionsResponse to IC in our patient cohort was a prognostic indicator of overall response to treatment. Further elucidation of predictors of response is needed for appropriate patient selection.