Oropharyngeal squamous cell carcinoma: Prognostic factors for development of distant metastases and oncological outcomes-Reference-Cited by-同舟云学术

Oropharyngeal squamous cell carcinoma: Prognostic factors for development of distant metastases and oncological outcomes

Published:2023-04-11 Issue:6 Volume:45 Page:1406-1417
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Mattioli Francesco¹,Lo Manto Alfredo¹^ORCID,Miglio Matteo¹^ORCID,Serafini Edoardo¹,Rossi Davide¹,Valerini Sara¹,Tonelli Roberto²³,Fermi Matteo⁴⁵^ORCID,Pugliese Giuseppe⁶,Bertolini Federica⁶,D'Angelo Elisa⁷,Depenni Roberta⁶,Dominici Massimo⁶,Lohr Frank R. H.⁷,Marchioni Daniele¹

Affiliation:

1. Department of Otorhinolaryngology‐Head and Neck Surgery University Hospital of Modena Modena Italy

2. Clinical and Experimental Medicine, Ph.D. Program University of Modena and Reggio Emilia Modena Italy

3. Respiratory Diseases Unit and Center for Rare Lung Disease, Department of Surgical and Medical Sciences University Hospital of Modena Modena Italy

4. Department of Otorhinolaryngology Head and Neck Surgery IRCCS Azienda Ospedaliero‐Universitaria di Bologna, Policlinico S. Orsola‐Malpighi Bologna Italy

5. Department of Specialist Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, Università di Bologna Bologna Italy

6. Department of Oncology and Hematology University Hospital of Modena Modena Italy

7. Radiation Oncology Unit, University Hospital of Modena Modena Italy

Abstract

AbstractBackgroundDistant metastasis (DM) development in Oropharyngeal Squamous Cell Carcinoma (OPSCC) represents an important prognostic factor. The identification of a phenotype of metastatic patients may better define therapeutic and follow‐up programs.MethodsWe included 408 patients with OPSCC, non‐metastatic at the time of diagnosis, and treated with curative intent. The Overall Survival (OS) analyses were performed and the impact of developing DM on survival was analyzed through Cox proportional‐hazard regression model.Results57 (14%) patients develop DM. 302 (74%) were p16+ OPSCC and 35 of them experienced DM. Advanced clinical stage, smoking, p16‐status, response to primary treatment, and loco‐regional relapse influence the DM rate. Only in the p16+ group, DM onset results in a greater impact on OS (p < 0.0001). Lung metastases have a better OS compared to non‐pulmonary ones (p = 0.049).ConclusionThis retrospective study shows a possible stratification of OPSCC patients based on the risk of the development of DMs.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27354

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