Tumor volume as a predictor of survival in advanced laryngeal cancer treated with total laryngectomy-Reference-Cited by-同舟云学术

Tumor volume as a predictor of survival in advanced laryngeal cancer treated with total laryngectomy

Published:2023-04-03 Issue:6 Volume:45 Page:1376-1388
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Hanubal Krishna S.¹^ORCID,Galochkina Zhanna²,Lee Ji‐Hyun²³,List Marna A.¹,Massini Tara C.⁴,Conrad Dustin⁵,Hughley Brian⁵,Danan Deepa⁵,DeJesus Reordan⁴,Hitchcock Kathryn⁶⁷,Nichols Spencer¹^ORCID,Mendenhall William⁶⁷^ORCID,Dziegielewski Peter T.⁵⁷

Affiliation:

1. College of Medicine University of Florida Gainesville Florida USA

2. Division of Quantitative Sciences University of Florida Health Cancer Center Gainesville Florida USA

3. Department of Biostatistics University of Florida Gainesville Florida USA

4. Department of Radiology University of Florida Gainesville Florida USA

5. Department of Otolaryngology University of Florida Gainesville Florida USA

6. Department of Radiation Oncology University of Florida Gainesville Florida USA

7. University of Florida Health Cancer Center Gainesville Florida USA

Abstract

AbstractBackgroundRecent literature shows that tumor volume (TV) in T3 laryngeal squamous cell carcinoma (LSCC) is associated with response to radiation therapy. The aim of this study was to evaluate the effect of TV on survival outcomes in patients undergoing total laryngectomy (TL).MethodsOne hundred and seventeen patients with LSCC undergoing TL between 2013 and 2020 at the University of Florida were included. TV was measured using a previously validated method on preoperative‐CT scans. Multivariable CoxPH models for overall survival (OS) and disease‐specific survival (DSS), metastasis‐free survival (MFS), and recurrence‐free survival (RFS) were developed with TV.ResultsMean age was 61.5 years and 81.2% were male. Higher TV was associated with decreased OS, MFS, DSS, and RFS with adjusted hazard ratios 1.02 (95%CI: 1.01, 1.03), 1.01, (95%CI: 1.00, 1.03), 1.03 (95%CI: 1.01, 1.06), and 1.02 (95%CI: 1.00, 1.03) respectively. TV >7.1 cc had worse prognoses.ConclusionsTV appears associated with decreased survival in LSCC treated with TL.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27351

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