Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score

Author:

Iwaki Hirotaka12,Blauwendraat Cornelis1,Makarious Mary B.1,Bandrés‐Ciga Sara1,Leonard Hampton L.1,Gibbs J. Raphael1,Hernandez Dena G.1,Scholz Sonja W.1ORCID,Faghri Faraz1,Nalls Mike A.12,Singleton Andrew B.1,Noyce Alastair J,Kaiyrzhanov Rauan,Middlehurst Ben,Kia Demis A,Tan Manuela,Houlden Henry,Morris Huw R,Plun‐Favreau Helene,Holmans Peter,Hardy John,Trabzuni Daniah,Quinn John,Bubb Vivien,Mok Kin Y,Kinghorn Kerri J.,Wood Nicholas W,Lewis Patrick,Schreglmann Sebastian,Lovering Ruth,R'Bibo Lea,Manzoni Claudia,Rizig Mie,Ryten Mina,Guelfi Sebastian,Escott‐Price Valentina,Chelban Viorica,Foltynie Thomas,Williams Nigel,Morrison Karen E.,Clarke Carl,Brice Alexis,Danjou Fabrice,Lesage Suzanne,Corvol Jean‐Christophe,Martinez Maria,Schulte Claudia,Brockmann Kathrin,Simón‐Sánchez Javier,Heutink Peter,Rizzu Patrizia,Sharma Manu,Gasser Thomas,Cookson Mark R,Bandres‐Ciga Sara,Blauwendraat Cornelis,Craig David W.,Billingsley Kimberley,Narendra Derek,Faghri Faraz,Raphael Gibbs J,Hernandez Dena G.,Keuren‐Jensen Kendall Van,Shulman Joshua M.,Iwaki Hirotaka,Leonard Hampton L.,Nalls Mike A.,Robak Laurie,Bras Jose,Guerreiro Rita,Lubbe Steven,Finkbeiner Steven,Mencacci Niccolo E.,Lungu Codrin,Singleton Andrew B,Scholz Sonja W.,Reed Xylena,Alcalay Roy N.,Gan‐Or Ziv,Rouleau Guy A.,Krohn Lynne,Hilten Jacobus J,Marinus Johan,Adarmes‐Gómez Astrid D.,Aguilar Miquel,Alvarez Ignacio,Alvarez Victoria,Barrero Francisco Javier,Yarza Jesús Alberto Bergareche,Bernal‐Bernal Inmaculada,Blazquez Marta,Bonilla‐Toribio Marta,Botía Juan A.,Boungiorno María Teresa,Buiza‐Rueda Dolores,Cámara Ana,Carrillo Fátima,Carrión‐Claro Mario,Cerdan Debora,Clarimón Jordi,Compta Yaroslau,Diez‐Fairen Monica,Dols‐Icardo Oriol,Duarte Jacinto,Duran Raquel,Escamilla‐Sevilla Francisco,Ezquerra Mario,Feliz Cici,Fernández Manel,Fernández‐Santiago Rubén,Garcia Ciara,García‐Ruiz Pedro,Gómez‐Garre Pilar,Heredia Maria Jose Gomez,Gonzalez‐Aramburu Isabel,Pagola Ana Gorostidi,Hoenicka Janet,Infante Jon,Jesús Silvia,Jimenez‐Escrig Adriano,Kulisevsky Jaime,Labrador‐Espinosa Miguel A.,Lopez‐Sendon Jose Luis,Munain Arregui Adolfo López,Macias Daniel,Torres Irene Martínez,Marín Juan,Marti Maria Jose,Martínez‐Castrillo Juan Carlos,Méndez‐del‐Barrio Carlota,González Manuel Menéndez,Mata Marina,Mínguez Adolfo,Mir Pablo,Rezola Elisabet Mondragon,Muñoz Esteban,Pagonabarraga Javier,Pastor Pau,Errazquin Francisco Perez,Periñán‐Tocino Teresa,Ruiz‐Martínez Javier,Ruz Clara,Rodriguez Antonio Sanchez,Sierra María,Suarez‐Sanmartin Esther,Tabernero Cesar,Tartari Juan Pablo,Tejera‐Parrado Cristina,Tolosa Eduard,Valldeoriola Francesc,Vargas‐González Laura,Vela Lydia,Vives Francisco,Zimprich Alexander,Pihlstrom Lasse,Toft Mathias,Koks Sulev,Taba Pille,Hassin‐Baer Sharon,Majamaa Kari,Siitonen Ari,Tienari Pentti,Okubadejo Njideka U.,Ojo Oluwadamilola O.,Kaiyrzhanov Coordinator ‐ Rauan,Shashkin Chingiz,Zharkinbekova Nazira,Akhmetzhanov Vadim,Aitkulova Akbota,Zholdybayeva Elena,Zharmukhanov Zharkyn,Kaishybayeva Gulnaz,Karimova Altynay,Sadykova Dinara,

Affiliation:

1. Laboratory of Neurogenetics, National Institute on AgingNational Institutes of Health Bethesda Maryland USA

2. Data Tecnica International Glen Echo Maryland USA

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Reference20 articles.

1. Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk;Nalls MA;bioRxiv,2019

2. Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

3. A common LRRK2 mutation in idiopathic Parkinson's disease;Gilks WP;Lancet,2005

4. G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort

5. LRRK2G2019S as a Cause of Parkinson's Disease in Ashkenazi Jews

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