Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis

Author:

Peng Zhen-Wei12,Ikenaga Naoki2,Liu Susan B.2,Sverdlov Deanna Y.2,Vaid Kahini A.2,Dixit Richa2,Weinreb Paul H.3,Violette Shelia3,Sheppard Dean4,Schuppan Detlef5,Popov Yury2

Affiliation:

1. Department of Oncology; The First Affiliated Hospital of Sun Yat-sen University; Guangzhou China

2. Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center; Harvard Medical School; Boston MA

3. Biogen, Inc.; Cambridge MA

4. Lung Biology Center; University of California, San Francisco School of Medicine; San Francisco CA

5. Institute of Translational Immunology and Research Center for Immune Therapy; University Medical Center; Mainz Germany

Funder

Biogen Idec, Inc.

Stomedix, Inc.

Department of Medicine (BIDMC)

Yat-sen University (Guangzhou, China)

National Natural Science Foundation of China

Pearl River S&T Nova Program

Publisher

Wiley

Subject

Hepatology

Reference50 articles.

1. Diagnosis and management of primary sclerosing cholangitis;Chapman;Hepatology,2009

2. Cholangiocarcinoma;Khan;Lancet,2005

3. Ductular reaction and its diagnostic significance;Roskams;Semin Diagn Pathol,1998

4. The cholangiopathies: disorders of biliary epithelia;Lazaridis;Gastroenterology,2004

5. Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies;Popov;Hepatology,2009

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