Comparison of Angiolytic Effects Between the 445‐nm Blue Laser and 532‐nm Pulsed KTP Laser

Author:

Nguyen Duy Duong12ORCID,Pang Jing‐Yin3,Novakovic Daniel14ORCID

Affiliation:

1. Voice Research Laboratory, Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia

2. National Hospital of Otorhinolaryngology Hanoi Vietnam

3. Department of Ear‐Nose‐Throat Khoo Teck Puat Hospital Yishun Central Singapore

4. The Canterbury Hospital Sydney New South Wales Australia

Abstract

ObjectiveThis study aimed to compare the selective absorption of the 445‐nm Blue laser (BL) and the 532‐nm pulsed potassium‐titanyl‐phosphate (KTP) laser by blood vessels.MethodsThirty‐six chicken eggs at day 14 of incubation were dissected to expose the chick chorioallantoic membrane (CAM). Third‐order vessels of the CAM were identified and irradiated using BL and KTP lasers using various settings at a laser‐to‐vessel distance of 3 mm using 0.4 mm fiber size. In total, 494 vessels segments were irradiated. Mean (standard deviation) number of irradiations for each setting was 26.0 (4.6), range from 15 to 39. Outcome measures included ablation rate (AR) and rupture rate (RR).ResultsThe two lasers were compared for AR and RR at long and medium pulse width (PW) associated with different power levels. At long PW (above 100 ms), BL showed significantly higher AR than KTP at high energy (600 mJ/pulse) and low energy (400 mJ/pulse); they did not show different AR and RR at medium energy levels (500 mJ/pulse). Using medium PW settings plus high and medium energy levels, BL and KTP showed relatively high AR and did not significantly differ in performance. However, at medium PW plus low energy (400–450 mJ/pulse), KTP showed significantly higher AR compared to BL.ConclusionAt long PW, BL appeared to show higher AR than KTP at high or low energy levels, but they showed equivalent performance at medium energy. At medium PW, both performed similarly from high to medium energy, but KTP appeared to perform better than BL at lower energy settings.Level of EvidenceNA Laryngoscope, 134:3220–3225, 2024

Publisher

Wiley

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