Epigenetic control of thymic Treg-cell development

Author:

Kitagawa Yohko1,Ohkura Naganari12,Sakaguchi Shimon13

Affiliation:

1. Department of Experimental Immunology; World Premier International Immunology Frontier Research Center; Osaka University; Suita Japan

2. Department of Frontier Research in Tumor Immunology; Graduate School of Medicine; Osaka University; Suita Japan

3. Department of Experimental Pathology; Institute for Frontier Medical Sciences; Kyoto University; Kyoto Japan

Funder

Japanese Science and Technology Agency

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference47 articles.

1. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals;Jaenisch;Nat. Genet.,2003

2. DNA methylation dynamics during in vivo differentiation of blood and skin stem cells;Bock;Mol. Cell,2012

3. Comprehensive methylome map of lineage commitment from haematopoietic progenitors;Ji;Nature,2010

4. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development;Ohkura;Immunity,2012

5. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases;Sakaguchi;J. Immunol.,1995

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