Patients with T+/lowNK+IL-2 receptor γ chain deficiency have differentially-impaired cytokine signaling resulting in severe combined immunodeficiency

Author:

Fuchs Sebastian12,Rensing-Ehl Anne1,Erlacher Miriam13,Vraetz Thomas1,Hartjes Lara1,Janda Ales13,Rizzi Marta1,Lorenz Myriam R.4,Gilmour Kimberly5,de Saint-Basile Geneviève678,Roifman Chaim M.9,Cheuk Steven1,Gennery Andrew10,Thrasher Adrian J.5,Fuchs Ilka1,Schwarz Klaus1411,Speckmann Carsten13,Ehl Stephan13

Affiliation:

1. Center for Chronic Immunodeficiency (CCI); University Medical Center and University of Freiburg; Freiburg Germany

2. Faculty of Biology; University of Freiburg; Freiburg Germany

3. Center of Pediatric and Adolescent Medicine; University Medical Center; Freiburg Germany

4. Institute for Transfusion Medicine; University of Ulm; Ulm Germany

5. Molecular Immunology Unit, Institute of Child Health (ICH); University College London (UCL); London UK

6. INSEM UMR 1163; Laboratory of Normal and Pathological Homeostasis of the Immune System; Paris France

7. Paris Descartes-Sorbonne Paris Cité University; Imagine Institute; Paris France

8. Centre d'Etudes des Déficits Immunitaires, Assistance Publique-Hôpitaux de Paris; Hôpital Necker; Paris France

9. The Canadian Centre for Primary Immunodeficiency; Division of Immunology and Allergy and Department of Pediatrics; the Jeffrey Modell Research Laboratory for the Diagnosis of Primary Immunodeficiency; the Hospital for Sick Children and the University of Toronto; Toronto Ontario Canada

10. Institute of Cellular Medicine; Newcastle University; Newcastle upon Tyne UK

11. Institute for Clinical Transfusion Medicine and Immunogenetics Ulm; German Red Cross Blood Service; Ulm Germany

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Baxter International

National Institute for Health Research

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

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