Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children-Reference-Cited by-同舟云学术

Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children

Published:2021-08-26 Issue:10 Volume:10 Page:1183-1194
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Aruldhas Blessed W.¹²³^ORCID,Quinney Sara K.²⁴⁵^ORCID,Overholser Brian R.²⁶,Heathman Michael A.⁷,Masters Andrea R.⁸,Ly Reynold C.²^ORCID,Gao Hongyu⁹,Packiasabapathy Senthil¹,Sadhasivam Senthilkumar¹

Affiliation:

1. Department of Anesthesia Indiana University School of Medicine Indianapolis Indiana USA

2. Division of Clinical Pharmacology Department of Medicine Indiana University School of Medicine Indianapolis Indiana USA

3. Department of Pharmacology and Clinical Pharmacology Christian Medical College Vellore India

4. Department of Obstetrics and Gynecology Indiana University School of Medicine Indianapolis Indiana USA

5. Center for Computational Biology and Bioinformatics Indiana University School of Medicine Indianapolis Indiana USA

6. Department of Pharmacy Practice Purdue University College of Pharmacy Indianapolis Indiana USA

7. Metrum Research Group Tariffville Connecticut USA

8. Clinical Pharmacology Analytical Core Indiana University Simon Comprehensive Cancer Center Indiana University School of Medicine Indianapolis Indiana USA

9. Department of Medical and Molecular Genetics Center for Medical Genomics Indiana University School of Medicine Indianapolis Indiana USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12687

Reference41 articles.

1. Pain Prevalence, Intensity, Assessment and Management in a Hospitalized Pediatric Population

2. Methadone-based Multimodal Analgesia Provides the Best-in-class Acute Surgical Pain Control and Functional Outcomes With Lower Opioid Use Following Major Posterior Fusion Surgery in Adolescents With Idiopathic Scoliosis

3. Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic Model

4. Interindividual Variability of the Clinical Pharmacokinetics of Methadone

5. Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19

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