Using physiologically‐based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet
Author:
Affiliation:
1. Clinical Pharmacology Alkermes, Inc. Waltham Massachusetts USA
2. Simcyp Division Certara UK Limited Sheffield UK
3. Seres Therapeutics Cambridge Massachusetts USA
Publisher
Wiley
Subject
Pharmacology (medical),Modelling and Simulation
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12675
Reference24 articles.
1. Syntheses of novel high affinity ligands for opioid receptors
2. In Vitro Pharmacological Characterization of Buprenorphine, Samidorphan, and Combinations Being Developed as an Adjunctive Treatment of Major Depressive Disorder
3. Use of Remifentanil in a Novel Clinical Paradigm to Characterize Onset and Duration of Opioid Blockade by Samidorphan, a Potent μ-Receptor Antagonist
4. Efficacy and Safety of a Combination of Olanzapine and Samidorphan in Adult Patients With an Acute Exacerbation of Schizophrenia
5. Effects of Olanzapine Combined With Samidorphan on Weight Gain in Schizophrenia: A 24-Week Phase 3 Study
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2. Combining samidorphan with olanzapine to mitigate weight gain as a side effect in schizophrenia treatment;Postępy Psychiatrii i Neurologii;2023
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