Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study

Author:

Ben Hassine Khalil12,Nava Tiago12,Théoret Yves3456,Nath Christa E.789,Daali Youssef1011,Kassir Nastya12,Lewis Victor13,Bredius Robbert G. M.14,Shaw Peter J.89,Bittencourt Henrique3456,Krajinovic Maja3456,Uppugunduri Chakradhara Rao Satyanarayana12,Ansari Marc12

Affiliation:

1. CANSEARCH Research Platform in Pediatric Oncology and Hematology Department of Pediatrics, Gynecology and Obstetrics University of Geneva Geneva Switzerland

2. Division of Pediatric Oncology and Hematology Department of Pediatrics, Gynecology and Obstetrics Geneva University Hospitals and University of Geneva Geneva Switzerland

3. Charles‐Bruneau Cancer Center Sainte‐Justine University Health Center (SJUHC) Montreal Quebec Canada

4. Department of Pharmacology and Physiology Faculty of Medicine University of Montreal Montreal Quebec Canada

5. Clinical Pharmacology Unit Sainte‐Justine University Health Center (SJUHC) Montreal Quebec Canada

6. Department of Pediatrics Faculty of Medicine University of Montreal Montreal Quebec Canada

7. Department of Biochemistry The Children’s Hospital at Westmead Sydney New South Wales Australia

8. The Cancer Centre for Children The Children’s Hospital at Westmead Sydney New South Wales Australia

9. Children's Hospital at Westmead Clinical School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia

10. Clinical Pharmacology and Toxicology Division Geneva University Hospitals and University of Geneva Geneva Switzerland

11. Faculty of Medicine & Sciences University of Geneva Geneva Switzerland

12. Genentech/RocheClinical Pharmacology South San Francisco California USA

13. Department of Pediatrics Alberta Children's Hospital Calgary Alberta Canada

14. Department of Pediatrics Leiden University Medical Center Leiden The Netherlands

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Oak Foundation

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Reference50 articles.

1. Graft‐rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics;Slattery JT;Bone Marrow Transplant,1995

2. Therapeutic Monitoring of Busulfan in Hematopoietic Stem Cell Transplantation

3. Association of busulfan area under the curve with veno‐occlusive disease following BMT;Dix SP;Bone Marrow Transplant,1996

4. Busulfan concentration and graft rejection in pediatric patients undergoing hematopoietic stem cell transplantation

5. Target dose adjustment of busulfan in pediatric patients undergoing bone marrow transplantation

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