Integrative chemogenomic analysis identifies small molecules that partially rescue ΔF508‐CFTR for cystic fibrosis-Reference-Cited by-同舟云学术

Integrative chemogenomic analysis identifies small molecules that partially rescue ΔF508‐CFTR for cystic fibrosis

Published:2021-05 Issue:5 Volume:10 Page:500-510
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Hodos Rachel A.¹²,Strub Matthew D.³⁴,Ramachandran Shyam⁵,Meleshkevitch Ella A.⁶,Boudko Dmitri Y.⁶,Bridges Robert J.⁶,Dudley Joel T.¹,McCray Paul B.³⁴

Affiliation:

1. Institute for Next Generation Healthcare Mount Sinai School of Medicine New York NY USA

2. Courant Institute for Mathematical Sciences New York University New York NY USA

3. Department of Pediatrics University of Iowa Carver College of Medicine Iowa City IA USA

4. Interdisciplinary Graduate Program in Genetics University of Iowa Iowa City IA USA

5. Editas Medicine Cambridge MA USA

6. Department of Physiology and Biophysics Rosalind Franklin University North Chicago IL USA

Funder

National Institutes of Health

Cystic Fibrosis Foundation

Roy J. Carver Charitable Trust

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12626

Reference45 articles.

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2. Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

3. Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

4. VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

5. Asthma and pulmonary function abnormalities in heterozygotes for cystic fibrosis transmembrane regulator gene mutations;Douros K;Int J Clin Exp Med,2008

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