Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis

Author:

Maharaj Anil R.1,Wu Huali1,Zimmerman Kanecia O.12,Speicher David G.3,Sullivan Janice E.4,Watt Kevin12,Al‐Uzri Amira5,Payne Elizabeth H.6,Erinjeri Jinson6,Lin Susan6,Harper Barrie1,Melloni Chiara1,Hornik Christoph P.12,

Affiliation:

1. Duke Clinical Research InstituteDuke University School of Medicine Durham North Carolina USA

2. Department of PediatricsDuke University School of Medicine Durham North Carolina USA

3. Division of Pediatric Critical CareRainbow Babies and Children's Hospital Cleveland Ohio USA

4. University of LouisvilleKosair Charities Pediatric Clinical Research Unit, and Norton Children's Hospital Louisville Kentucky USA

5. Oregon Health and Science University Portland Oregon USA

6. The Emmes CompanyLLC Rockville Maryland USA

Funder

National Institute of Child Health and Human Development

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference44 articles.

1. Prevalence of Obesity and Severe Obesity in US Children, 1999–2016

2. Centers for Disease Control and Prevention (CDC).Percentile data files with LMS values. CDC web site.https://www.cdc.gov/growthcharts/percentile_data_files.htm. Updated August 4 2009. Accessed July 18 2019.

3. Drug dosing in obese adults

4. Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients

5. Effect of Obesity on the Pharmacokinetics of Drugs in Humans

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