Evaluation of pH change effects on the HSA folding and its drug binding characteristics, a computational biology investigation

Author:

Gomari Mohammad Mahmoudi12,Rostami Neda3,Faradonbeh Davood Rabiei4,Asemaneh Hamid Reza5,Esmailnia Giti2,Arab Shahriar6ORCID,Farsimadan Marziye7,Hosseini Arshad2,Dokholyan Nikolay V.8ORCID

Affiliation:

1. Student Research Committee, Iran University of Medical Sciences Tehran Iran

2. Department of Medical Biotechnology, Faculty of Allied Medicine Iran University of Medical Sciences Tehran Iran

3. Department of Chemical Engineering, Faculty of Engineering Arak University Arak Iran

4. Department of Medical Biotechnology School of Advanced Technologies in Medicine, Tehran University of Medical Sciences Tehran Iran

5. Polymer Research Center, Department of Chemical Engineering Razi University Kermanshah Iran

6. Department of Biophysics School of Biological Sciences, Tarbiat Modares University Tehran Iran

7. Department of Biology, Faculty of Sciences University of Guilan Rasht Iran

8. Department of Pharmacology, Department of Biochemistry & Molecular Biology Pennsylvania State University College of Medicine Hershey Pennsylvania USA

Funder

Iran University of Medical Sciences

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Reference88 articles.

1. Protein Binding: What Does it Mean?

2. Exploring the interaction between the antiallergic drug, tranilast and human serum albumin: Insights from calorimetric, spectroscopic and modeling studies

3. The effect of pH on the binding characteristics of paracetamol to bovine serum albumin;Agbanyim AN;Int J Sci Res Publ,2016

4. Interactive Association of Drugs Binding to Human Serum Albumin

5. Ceftriaxone binding to human serum albumin: competition with bilirubin;Brodersen R;Mol Pharmacol,1989

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