Production of tert ‐butyl (3 R ,5 S )‐6‐chloro‐3,5‐dihydroxyhexanoate using carbonyl reductase coupled with glucose dehydrogenase with high space

Production of tert ‐butyl (3 R ,5 S )‐6‐chloro‐3,5‐dihydroxyhexanoate using carbonyl reductase coupled with glucose dehydrogenase with high space–time yield

Published:2019-09-12 Issue:1 Volume:36 Page:
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Zhang Xiao‐Jian¹²,Zheng Ling¹²,Wu Di¹²,Zhou Rong¹²,Liu Zhi‐Qiang¹²^ORCID,Zheng Yu‐Guo¹²^ORCID

Affiliation:

1. The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral ChemicalsZhejiang University of Technology Hangzhou China

2. Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and BioengineeringZhejiang University of Technology Hangzhou China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.2900

Reference30 articles.

1. Effect of rosuvastatin on risk markers for venous thromboembolism in cancer

2. Rosuvastatin use improves measures of coagulation in patients with venous thrombosis

3. Targeting HMGB1/TLR4 axis and miR-21 by rosuvastatin: role in alleviating cholestatic liver injury in a rat model of bile duct ligation

4. Large‐scale synthesis of tert‐ butyl ( 3R,5S )‐6‐chloro‐3,5‐dihydroxyhexanoate by a stereoselective carbonyl reductase with high substrate concentration and product yield

5. Improvement of carbonyl reductase activity for the bioproduction of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate

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