Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC
Author:
Publisher
Wiley
Subject
Molecular Biology,Biochemistry,Structural Biology
Reference44 articles.
1. In vitro evolution of a T cell receptor with high affinity for peptide/MHC;Holler;Proc Natl Acad Sci USA,2000
2. Directed evolution of human T-cell receptors with picomolar affinities by phage display;Li;Nat Biotechnol,2005
3. Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity;Dunn;Protein Sci,2006
4. High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1. CDR2 or CDR3;Chlewicki;J Mol Biol,2005
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