Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation-Reference-Cited by-同舟云学术

Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation

Published:2013-08-01 Issue:9 Volume:22 Page:1161-1173
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

J. Landau Mark¹²,Sharma Hitesh¹,Anderson Karen S.¹²

Affiliation:

1. Department of Pharmacology; Yale University School of Medicine; 333 Cedar Street New Haven Connecticut 06510

2. Department of Molecular Biophysics and Biochemistry; Yale University School of Medicine; 333 Cedar Street New Haven Connecticut 06510

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/pro.2300/fullpdf

Reference43 articles.

1. Targeting protein-protein interactions by rational design: mimicry of protein surfaces;Fletcher;J R Soc Interface,2006

2. Disruption of protein-protein interactions: towards new targets for chemotherapy;Loregian;J Cell Physiol,2005

3. Atomic structure of thymidylate synthase: target for rational drug design;Hardy;Science,1987

4. Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site;Schiffer;Biochemistry,1995

5. The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits;Anderson;Biochemistry,1999

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea;Open Biology;2020-11

2. Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors;Bioorganic & Medicinal Chemistry Letters;2020-08

3. Targeting Kinetoplastid and Apicomplexan Thymidylate Biosynthesis as an Antiprotozoal Strategy;Current Medicinal Chemistry;2019-09-20

4. Crystal structures of nematode (parasitic T. spiralis and free living C. elegans ), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS;Journal of Molecular Graphics and Modelling;2017-10

5. Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR;Protein Engineering, Design and Selection;2017-02-06