Affiliation:
1. Nuffield Department of Primary Care Health Sciences University of Oxford, Radcliffe Observatory Quarter Oxford UK
2. National Institute for Health Research Oxford Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust Oxford UK
Abstract
AbstractObjectiveThe objective of this study was to investigate whether pausing a weight loss program for a defined period of time could enhance weight loss and reduce attrition.MethodsFive databases and two trial registries were searched from inception to July 2023. Randomized‐controlled trials of adults with overweight and/or obesity were included if they compared planned‐pause interventions with continuous energy restriction (CER), usual care, or a minimal intervention. To be included, the weight loss intervention must have incorporated a pause of at least 1 week. Pooled mean differences for weight change and risk ratios for attrition were calculated using random‐effects meta‐analyses.ResultsNine intervention arms (N = 796 participants, 77% female) were included. Pooled results did not detect a significant difference in weight change between planned pauses and CER interventions at the end of the active intervention at a median 26 weeks (planned pauses vs. CER mean: −7.09 vs. −7.0 kg; mean difference: −0.09 kg; 95% CI: −1.10 to 0.93) or at final follow‐up at a median 52 weeks (planned pauses vs. CER mean: −6.91 vs. −6.19 kg; mean difference: −0.72 kg; 95% CI: −2.92 to 1.48). There was no difference in attrition between planned pauses and CER interventions at the end of the active intervention (risk ratio: 1.20, 95% CI: 0.82 to 1.75) or at final follow‐up (risk ratio: 1.04, 95% CI: 0.89 to 1.22).ConclusionsPlanned pauses were consistently found to be no more or less effective than CER for weight loss or attrition.
Funder
Medical Research Council
National Institute for Health and Care Research
NIHR Oxford Biomedical Research Centre
Novo Nordisk UK Research Foundation