Evaluation of the Pharmacokinetics, Safety, and Tolerability of a Single Oral Dose of Pyrimethamine in Healthy Male Subjects of Japanese and European Ancestry-Reference-Cited by-同舟云学术

Evaluation of the Pharmacokinetics, Safety, and Tolerability of a Single Oral Dose of Pyrimethamine in Healthy Male Subjects of Japanese and European Ancestry

Published:2020-01-16 Issue:6 Volume:9 Page:768-773
ISSN:2160-763X
Container-title:Clinical Pharmacology in Drug Development
language:en
Short-container-title:Clinical Pharmacology in Drug Development

Author:

Iida Takayuki¹,Nand Romina A.²,Ino Hiroko¹,Ogura Hirofumi¹,Itoh Hiroshi³,Igarashi Harue⁴,Numachi Yotaro⁵,Gross Annette S.²

Affiliation:

1. Clinical Pharmacology Office Medicines Development, Japan Development Division, GlaxoSmithKline K.K. Tokyo Japan

2. Clinical Pharmacology Modelling & Simulation GlaxoSmithKline R&D Ermington Australia

3. Biomedical Data Sciences Department Japan Development Division, GlaxoSmithKline K.K. Tokyo Japan

4. Pre‐Clinical Development Department Japan Development Division, GlaxoSmithKline K.K. Tokyo Japan

5. Medicines Development Japan Development Division, GlaxoSmithKline K.K. Tokyo Japan

Funder

GlaxoSmithKline

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.771

Reference26 articles.

1. Dihydrofolate reductase as a therapeutic target

2. Toxoplasmosis

3. Adverse Event Profile of Pyrimethamine-Based Therapy in Toxoplasmosis: A Systematic Review

4. Studies in Human Malaria

5. Treatment of Uveitis with Pyrimethamine (Daraprim)

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