Aspirin intake and head and neck cancer: A pooled analysis within the <scp>INHANCE</scp> consortium-Reference-Cited by-同舟云学术

Aspirin intake and head and neck cancer: A pooled analysis within the INHANCE consortium

Published:2024-01-16 Issue: Volume: Page:
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Sassano Michele¹²^ORCID,Taborelli Martina³,Boccia Stefania²⁴,Cadoni Gabriella⁵⁶,La Vecchia Carlo⁷,Garavello Werner⁸,Lazarus Philip⁹,Lee Yuan‐Chin Amy¹⁰,Hashibe Mia¹⁰,Boffetta Paolo¹¹¹

Affiliation:

1. Department of Medical and Surgical Sciences University of Bologna Bologna Italy

2. Section of Hygiene, Department of Life Sciences and Public Health Università Cattolica del Sacro Cuore Rome Italy

3. Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS Aviano Italy

4. Department of Woman and Child Health and Public Health – Public Health Area Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy

5. Dipartimento Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa‐Collo Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italy

6. Dipartimento Patologia Testa Collo e Organi di Senso, Facoltà Medicina e Chirurgia Università Cattolica Sacro Cuore Roma Italy

7. Department of Clinical Sciences and Community Health University of Milan Milan Italy

8. Department of Otorhinolaryngology School of Medicine and Surgery, University of Milano‐Bicocca Milan Italy

9. Department of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical Sciences, Washington State University Spokane Washington USA

10. Division of Public Health, Department of Family & Preventive Medicine and Huntsman Cancer Institute University of Utah School of Medicine Salt Lake City Utah USA

11. Stony Brook Cancer Center Stony Brook University Stony Brook New York USA

Abstract

AbstractBackgroundAspirin intake might be inversely associated with head and neck cancer (HNC). Thus, we investigated this relationship within the International Head and Neck Cancer Epidemiology (INHANCE) consortium.MethodsFour case–control studies within the INHANCE consortium were included (2024 cases, 4196 controls). Study‐specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression and subsequently pooled with DerSimonian‐Laird random‐effects model. Nonlinearity of the relationship between duration of intake and HNC was modeled with fractional polynomials.ResultsAspirin was inversely associated with HNC overall (OR = 0.48; 95% CI: 0.26, 0.91). Results for laryngeal cancer were similar (OR = 0.54; 95% CI: 0.30, 0.96). Analysis on duration of intake confirmed findings for HNC overall, showing also inverse associations for oropharyngeal and laryngeal cancer.ConclusionsThis study suggests that aspirin intake may reduce the risk of HNC, driven mainly by decreases in risk for laryngeal and oropharyngeal cancer.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Fondazione AIRC per la ricerca sul cancro ETS

National Institutes of Health

National Institute of Dental and Craniofacial Research

National Cancer Institute

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27638

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