1. Massachusetts College of Pharmacy and Health Sciences University Boston Massachusetts
2. Department of Obstetrics and Gynecology Brigham and Women's Hospital Boston Massachusetts
3. These authors contributed equally to this work
4. Harvard Medical School Boston Massachusetts
5. Department of Pathology Brigham and Women's Hospital Boston Massachusetts
6. Medical and Population Genetics Program Broad Institute of MIT and Harvard Cambridge Massachusetts
7. Manchester Academic Health Science Centre University of Manchester Manchester United Kingdom