Evaluation of the safety, pharmacodynamic, and pharmacokinetic effects following oral coadministration of immediate-release morphine with ethanol in healthy male participants

Author:

Setnik Beatrice1,Sokolowska Marta2,Johnson Franklin3,Oldenhof John2,Romach Myroslava2

Affiliation:

1. Pfizer Inc.; Durham North Carolina USA

2. Kendle Early Phase; Toronto Ontario Canada

3. Alpharma, Inc.; Bridgewater New Jersey USA

Publisher

Wiley

Subject

Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology

Reference39 articles.

1. Actavis Elizabeth LLC 2010 Kadian (morphine sulfate extended-release) prescribing information http://www.kadian.com/NR/rdonlyres/CD1A5F24-38CB-4F64-8434-2C6367C2CD1F/0/FullPrescribingInformationandMedicationGuide.pdf

2. Comparison of the effects of therapeutic doses of meptazinol and a dextropropoxyphene/paracetamol mixture alone and in combination with ethanol on ventilatory function and saccadic eye movements;Ali;Br J Clin Pharmacol,1985

3. Centers for Disease Control and Prevention Frequently asked questions http://www.cdc.gov/alcohol/faqs.htm 2012

4. The effect of codeine phosphate on the absorption of ethyl alcohol;Cudworth;Br J Clin Pharmacol,1975

5. Ethanol and methadone in man: a possible drug interaction;Cushman;Drug Alcohol Depend,1978

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