Expression analysis of <scp>SOX2</scp> and <scp>SOX9</scp> in patients with oral squamous cell carcinoma-Reference-Cited by-同舟云学术

Expression analysis of SOX2 and SOX9 in patients with oral squamous cell carcinoma

Published:2024-08-23 Issue: Volume: Page:
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Steen Sonja¹,Horn Dominik²,Flechtenmacher Christa³⁴,Hoffmann Jürgen¹,Freier Kolja²,Ristow Oliver¹,Hess Jochen⁵,Moratin Julius¹^ORCID

Affiliation:

1. Department of Oral and Cranio‐Maxillofacial Surgery University of Heidelberg Heidelberg Germany

2. Department of Oral and Cranio‐Maxillofacial Surgery Saarland University Hospital Homburg Germany

3. Tissue Bank of the National Center for Tumor Diseases (NCT) Heidelberg Germany

4. Institute of Pathology University of Heidelberg Heidelberg Germany

5. Department of Otorhinolaryngology – Head and Neck Surgery University of Heidelberg Heidelberg Germany

Abstract

AbstractBackgroundLately SOX2 and SOX9, transcription factors associated with stemness‐like phenotypes of cancer cells, have been linked to tumor growth, metastasis, and resistance to therapy.MethodsThis study aimed on evaluating the expression of SOX2 and SOX9 in a large cohort of patients with OSCC including primary and recurrent tumors and corresponding lymph node metastases. Semiautomatic digital pathology scoring was used to determine protein expression and survival analysis was performed to evaluate its prognostic significance.ResultsWe found a significant downregulation of SOX9 from primary disease to lymph node metastases (p < 0.001). SOX9 expression and the subgroup SOX2lowSOX9high were significantly correlated with worse overall survival (p < 0.05). Additionally, SOX2lowSOX9high expression pattern was confirmed as independent prognosticator for overall survival.ConclusionsThese results indicate the relevant role of SOX2 and SOX9 in patients with OSCC and show the clinical relevance for further investigation on the molecular mechanisms underlying SOX‐related gene expression.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27925

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