The Effect of the Cathepsin K Inhibitor ONO-5334 on Trabecular and Cortical Bone in Postmenopausal Osteoporosis: The OCEAN Study-Reference-Cited by-同舟云学术

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The Effect of the Cathepsin K Inhibitor ONO-5334 on Trabecular and Cortical Bone in Postmenopausal Osteoporosis: The OCEAN Study

Published:2014-02-19 Issue:3 Volume:29 Page:629-638
ISSN:0884-0431
Container-title:Journal of Bone and Mineral Research
language:en
Short-container-title:J Bone Miner Res

Author:

Engelke Klaus¹²,Nagase Shinichi³,Fuerst Thomas⁴,Small Maria³,Kuwayama Tomohiro³,Deacon Stephen³,Eastell Richard⁵,Genant Harry K⁶

Affiliation:

1. Synarc Inc; Hamburg Germany

2. Institute of Medical Physics; University of Erlangen; Germany

3. Ono Pharma UK Ltd; London UK

4. Synarc Inc; San Francisco CA USA

5. Department of Human Metabolism; University of Sheffield; Sheffield UK

6. Department of Radiology; University of California; San Francisco CA USA

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference19 articles.

1. Alignment/phylogeny of the papain superfamily of cysteine proteases;Berti;J Mol Biol.,1995

2. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency;Gelb;Science.,1996

3. Efficacy of ONO-5334, a cathepsin K inhibitor, on bone mass and strength in ovariectomized cynomolgus monkeys;Yamada;J Bone Miner Res.,2010

4. Pharmacodynamic effects on biochemical markers of bone turnover and pharmacokinetics of the cathepsin K inhibitor, ONO-5334, in an ascending multiple-dose, Phase 1 study;Nagase;J Clin Pharmacol.,2012

5. Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: the OCEAN study;Eastell;J Bone Miner Res.,2011

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