Replacement of Isobutyl by Trifluoromethyl in Pepstatin A Selectively Affects Inhibition of Aspartic Proteinases-Reference-Cited by-同舟云学术

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Replacement of Isobutyl by Trifluoromethyl in Pepstatin A Selectively Affects Inhibition of Aspartic Proteinases

Published:2005-11-24 Issue:1 Volume:7 Page:181-186
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Binkert Christoph,Frigerio Massimo,Jones Andrew,Meyer Solange,Pesenti Cristina,Prade Lars,Viani Fiorenza,Zanda Matteo

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference45 articles.

1. Organofluorine Chemistry

2. Steric effects. I. Esterification and acid-catalyzed hydrolysis of esters

3. Fluorine substituent effects (on bioactivity)

4. Atropisomerism, Biphenyls, and Fluorine: A Comparison of Rotational Barriers and Twist Angles

5. Fluorinated Carbonyl and Olefinic Compounds: Basic Character and Asymmetric Catalytic Reactions

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1. Dual effects of Pepstatin A on Plasmodium falciparum asexual blood-stage and early gametocyte development;2024-07-12

2. Synthesis and biological evaluation of selective Pepstatin based trifluoromethylated inhibitors of Cathepsin D;European Journal of Medicinal Chemistry;2024-03

3. N-Silylimine of Trifluoropyruvate in the Asymmetric Synthesis of Trifluoroalanine Derivatives;Journal of Organic and Pharmaceutical Chemistry;2023-08-21

4. Synthesis and Biological Evaluation of Selective Pepstatin Based Trifluoromethylated Inhibitors of Cathepsin D;2023

5. Highly stereoselective multigram scale synthesis of (3S,4S)-Statine and (3S,4S)-N-Benzylstatine;Results in Chemistry;2022-01

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