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Effects of enzastaurin and its metabolites on the QT interval in cancer patients

  • Published:2015-08-17 Issue:1 Volume:56 Page:101-108
  • ISSN:0091-2700
  • Container-title:The Journal of Clinical Pharmacology
  • language:en
  • Short-container-title:The Journal of Clinical Pharmacology

Author:

Welch Pamela A.1,Ng Wee Teck2,Darstein Christelle L.3,Musib Luna4,Lesimple Thierry5

Affiliation:

1. Pamela A. Welch's work on this article was performed while employed by Eli Lilly and Company; Indianapolis; IN USA

2. Eli Lilly and Company; Indianapolis; IN USA

3. Novartis Pharma AG; Postfach; Basel Switzerland

4. Genentech Inc; San Francisco; CA USA

5. Comprehensive Cancer Center and Biotrial; Rennes; France

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference13 articles.

1. Crump M Leppä S Fayad LE ASH Annual Meeting and Exposition 2013 371

2. Graff JR McNulty AM Hanna KR Cancer Res 2005 65 16) 7462 7469

3. 2005 http://www.fda.gov/downloads/RegulatoryInformation/Guidances/ucm129357.pdf

4. Phase 1 dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer;Carducci;J Clin Oncol.,2006

5. Altered ventricular repolarization during hypoglycaemia in patients with diabetes;Marques;Diabet Med.,1997

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