Affiliation:
1. The Second Clinical Medical College, Jinan University, Shenzhen Shenzhen China
2. Department of Hepatobiliary Surgery Zhongshan People's Hospital (Zhongshan Hospital Affiliated to Sun Yat‐sen University) Zhongshan China
3. Department of General Surgery The Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University Nanchang China
4. Division of Hepatobiliary and Pancreas Surgery, Department of General Surgery The Second Clinical Medical College, The First Affiliated Hospital, Shenzhen People's Hospital, Jinan University, Southern University of Science and Technology Shenzhen China
5. Division of Hepatobiliary and Pancreas Surgery, Department of General Surgery The First Clinical Medical College of Nanchang University, The First Affiliated Hospital of Nanchang University Nanchang China
Abstract
AbstractObjectiveTo investigate the influencing factors affecting the occurrence of microvascular invasion (MVI) and the prognosis of hepatocellular carcinoma (HCC) patients treated with hepatectomy, and to explore how MVI affects prognosis in subgroups with different prognostic factors.MethodsClinical data of a total of 1633 patients treated surgically for HCC in four treatment centers were included, including 754 patients with MVI. By using the Cox risk regression model and the Mann–Whitney U‐test, the common independent influences on prognosis and MVI were made clear. The incidence of MVI in various subgroups was then examined, as well as the relationship between MVI in various subgroups and prognosis.ResultsThe Cox risk regression model showed that MVI, Child–Pugh classification, alpha‐fetoprotein (AFP), hepatocirrhosis, tumor diameter, lymphocyte‐to‐monocyte ratio (LMR), and, Barcelona clinic liver cancer (BCLC) grade were independent determinants of overall survival (OS), and MVI, AFP, hepatocirrhosis, tumor diameter, and LMR were influencing determinants for disease‐free survival (DFS). The receiver operating characteristic (ROC) curve showed that MVI was most closely associated with patient prognosis compared to other prognostic factors. AFP, hepatocirrhosis, tumor diameter, and LMR were discovered to be common influences on the prognosis of patients with HCC and MVI when combined with the results of the intergroup comparison of MVI. After grouping, it was showed that patients with hepatocirrhosis, positive AFP (AFP ≥ 20 ng/mL), tumor diameter >50 mm, and LMR ≤3.4 had a significantly higher incidence of MVI than patients in other subgroups, and all four subgroups of MVI‐positive patients had higher rates of early recurrence and mortality (p < 0.05).ConclusionsMVI was found to be substantially linked with four subgroups of HCC patients with hepatocirrhosis, positive AFP, tumor diameter >50 mm, and LMR ≤3.4, and the prognosis of MVI‐positive patients in all four subgroups tended to be worse.
Funder
Basic and Applied Basic Research Foundation of Guangdong Province
Cited by
1 articles.
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