Incidence of maternal venous thromboembolism in China: A systematic review and meta‐analysis

Abstract

AbstractBackgroundVenous thromboembolism (VTE) is one of the primary causes of maternal death. Although many studies have reported maternal VTE, no study has estimated the incidence of it in China.ObjectivesThe aim of this work was to estimate the incidence of maternal VTE in China and to compare the risk factors for it.Search strategyThe authors searched eight platforms and databases including PubMed, Embase, and Cochrane Library from inception to April 2022, with the search terms “venous thromboembolism” AND “puerperium (pregnancy)” AND “incidence” AND “China.”Selection criteriaStudies provide data to calculate the incidence of maternal VTE among Chinese patients.Data collection and analysisThe authors made a standardized table to collect data and calculated the incidence and 95% confidence intervals (CIs), founding source of heterogeneity by subgroup analysis and meta‐regression and judging publication bias by funnel plot and Egger test.Main resultsThe included 53 papers with a total sample size of 3 813 871 patients had 2539 cases of VTE, and the incidence of maternal VTE in China was 0.13% (95% CI, 0.11–0.16; P < 0.001).ConclusionsThe trend in the incidence of maternal VTE in China is stable. Cesarean section and advanced age are associated with a higher incidence of VTE.