Long‐term exposure to extremely low‐dose of nicotine and 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) induce non‐malignant breast epithelial cell transformation through activation of the a9‐nicotinic acetylcholine receptor‐mediated signaling pathway

Author:

Fararjeh Abdul‐Fattah Salah1ORCID,Tu Shih‐Hsin234,Chen Li‐Ching235,Cheng Tzu‐Chun6,Liu Yun‐Ru57,Chang Hang‐Lung8,Chang Hui‐Wen9,Huang Chi‐Cheng41011,Wang Hwa‐Chain Robert12,Hwang‐Verslues Wendy W.13,Wu Chih‐Hsiung48,Ho Yuan‐Soon56914

Affiliation:

1. PhD Program for Cancer Molecular Biology and Drug DiscoveryCollege of Medical Science and Technology, Taipei Medical University and Academia Sinica Taipei Taiwan

2. Breast Medical Center, Taipei Medical University Hospital Taipei Taiwan

3. Taipei Cancer Center, Taipei Medical University Taipei Taiwan

4. Department of Surgery, School of Medicine, College of MedicineTaipei Medical University Taipei Taiwan

5. TMU Research Center of cancer Translational MedicineTaipei Medical University Taipei Taiwan

6. Graduate Institute of Medical Sciences, College of MedicineTaipei Medical University Taipei Taiwan

7. Joint Biobank, Office of Human ResearchTaipei Medical University Taipei Taiwan

8. Department of General SurgeryEn Chun Kong Hospital New Taipei City Taiwan

9. Department of Laboratory MedicineTaipei Medical University Hospital Taipei Taiwan

10. School of Medicine, College of Medicine, Fu‐Jen Catholic University New Taipei City Taiwan

11. Department of Surgery, Fu‐Jen Catholic University Hospital New Taipei City Taiwan

12. Department of Biomedical and Diagnostic SciencesCollege of Veterinary Medicine, University of Tennessee Knoxville Tennessee, USA

13. Genomics Research CenterAcademia Sinica Taipei Taiwan

14. School of Medical Laboratory Science and BiotechnologyCollege of Medical Science and Technology, Taipei Medical University Taipei Taiwan

Funder

Ministry of Science and Technology

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Management, Monitoring, Policy and Law,Toxicology,General Medicine

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