Affiliation:
1. Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study Department of Pharmacy and Pharmacology Hengyang Medical School University of South China Hengyang 421001 China
2. State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China
3. Clinical Research Institute The Affiliated Nanhua Hospital Hengyang Medical School University of South China Hengyang 421001 China
Abstract
AbstractConventional chemotherapy (CT) is associated with severe side effects and inducible resistance, making it difficult to meet clinical requirements, forcing the development of new multifunctional prodrugs for precision medicine. In recent decades, researchers and clinicians have focused on developing of multifunctional chemotherapeutic prodrugs with tumor‐targeting capability, activatable and traceable chemotherapeutic activity, as a powerful tool to improve theranostic outcomes in cancer treatment. The conjugates of near‐infrared (NIR) organic fluorophores and chemotherapy reagents create an exciting avenue for real‐time monitoring of drug delivery and distribution, as well as the combination of chemotherapy and photodynamic therapy (PDT). Therefore, there are great opportunities for researchers to conceive and exploit multifunctional prodrugs that can visualize chemo‐drugs release and tumor treatment in vivo. In this review, the design strategy and the recent progress of multifunctional organic chemotherapeutic prodrugs for activating NIR fluorescence imaging‐guided therapy are described and discussed in detail. Finally, the prospects and challenges of multifunctional chemotherapeutic prodrugs for NIR fluorescence imaging‐guided therapy are provided.
Funder
University of South China
State Key Laboratory of Chemo/Biosensing and Chemometrics
Subject
Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献