Sunflower Pollen‐Derived Microspheres Selectively Absorb DNA for microRNA Detection-Reference-Cited by-同舟云学术

Sunflower Pollen‐Derived Microspheres Selectively Absorb DNA for microRNA Detection

Published:2024-07-16 Issue: Volume: Page:
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Yang Yao¹,Mou Ziye²,Liu Qian³,Wang Bin¹,Luo Chenjing⁴,Xu Yuhang¹,Huang Qiuhong²,He Binfeng²,Chang Kai⁵,Wang Guansong¹,You Zaichun²,Qian Hang¹²^ORCID

Affiliation:

1. Institute of Respiratory Diseases Xinqiao Hospital Chongqing Key Laboratory of Precision Medicine and Prevention of Major Respiratory Diseases Third Military Medical University Chongqing 400037 China

2. Department of General Practice Xinqiao Hospital Third Military Medical University. Chongqing 400037 China

3. Laboratory of Pharmacy and Chemistry Laboratory of Tissue and Cell Biology Lab Teaching & Management Center Chongqing Medical University Chongqing 400016 China

4. Department of Pharmacy The Second Affiliated Hospital of Army Medical University Chongqing 400037 China

5. School of Chemistry and Chemical Engineering Southwest University Chongqing 400715 China

Abstract

AbstractHerein, we report the finding that a naturally sunflower pollen‐derived microspheres (HSECs) with hierarchical structures can selectively absorb polyC and polyA with high efficiency and affinity. HSECs exhibit the capability to selectively absorb polyC and polyA ssDNA under neutral and acidic conditions. It has been observed that the presence of metal cations, specifically Ca2+, enhances the absorption efficiency of HSECs. Mechanically, this absorption phenomenon can be attributed to both electrostatic interactions and cation‐π interactions. Such an appealing property enables the functionalization of HSECs for broad potential biomedical applications, such as microRNA detection.

Funder

National Natural Science Foundation of China

Publisher

Wiley

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