Improved Cytotoxicity and Induced Apoptosis in HeLa Cells by Co‐loading Vitamin E Succinate and Curcumin in Nano‐MIL‐88B‐NH2

Abstract

AbstractOne of the strategies for improved therapeutic effects in cancer therapy is combination chemotherapy. In this study, a flexible nano‐MOF (Fe‐MIL‐88B‐NH2) was synthesized in a sonochemical process, then co‐loaded with α‐tocopheryl succinate (TOS) and curcumin (CCM). The anticancer activity of co‐loaded Fe‐MIL‐88B‐NH2 (Fe‐MIL‐88B‐NH2/TOS@CCM) against the HeLa cells was compared with that of the single‐loaded counterpart (Fe‐MIL‐88B‐NH2@CCM). MTT analysis indicates improved cytotoxicity of Fe‐MIL‐88B‐NH2/TOS@CCM. The data from the cell apoptosis assay indicated more apoptosis in the case of the co‐loaded nano‐MOF. This study indicates the positive effect of the presence of TOS on enhancing the anticancer effect of Fe‐MIL‐88B‐NH2@CCM to prepare a more efficient drug delivery nanosystem.