Tunable Toxicity of Bufadienolides is Regulated through a Configuration Inversion Catalyzed by a Short‐Chain Dehydrogenase/Reductase-Reference-Cited by-同舟云学术

Tunable Toxicity of Bufadienolides is Regulated through a Configuration Inversion Catalyzed by a Short‐Chain Dehydrogenase/Reductase

Published:2022-10-18 Issue:22 Volume:23 Page:
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Ye Ge¹,Huang Weihuan²,Chen Zeping¹,Zhong Hao¹,Zhong Junhao¹,Guo Xiaoxin¹,Huang Yuheng¹,Kandalai Shruthi³⁴,Zhou Xiaozhuang³⁴,Zhang Nan³⁴,Zhou Yang⁵,Zheng Qingfei³⁴⁶^ORCID,Tian Haiyan¹

Affiliation:

1. Institute of Traditional Chinese Medicine and Natural Products International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China College of Pharmacy Jinan University 855 Xingye East Avenue 510632 Guangzhou P. R. China

2. Key Laboratory of Regenerative Medicine Ministry of Education Jinan University 601 West Huangpu Avenue 510632 Guangzhou P. R. China

3. Department of Radiation Oncology College of Medicine The Ohio State University 420 W. 12th Ave 43210 Columbus Ohio USA

4. Center for Cancer Metabolism James Comprehensive Cancer Center The Ohio State University 420 W. 12th Ave 43210 Columbus Ohio USA

5. Guangzhou City Key Laboratory of Precision Chemical Drug Development College of Pharmacy Jinan University 855 Xingye East Avenue 510632 Guangzhou P. R. China

6. Department of Biological Chemistry and Pharmacology College of Medicine The Ohio State University 420 W. 12th Ave 43210 Columbus Ohio USA

Funder

Guangzhou Municipal Science and Technology Project

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.202200473

Reference32 articles.

2. Bufadienolides and their antitumor activity

3. Bufadienolides of plant and animal origin

5. Molecular mechanisms of bufadienolides and their novel strategies for cancer treatment

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