Oxidation‐Responsive Supramolecular Hydrogels Based on Glucosamine Derivatives with an Aryl Sulfide Group

Author:

Ali Onaza1,Okumura Bioru2,Shintani Yuki1,Sugiura Shintaro1,Shibata Aya2,Higashi Sayuri L.134ORCID,Ikeda Masato12456ORCID

Affiliation:

1. United Graduate School of Drug Discovery and Medical Information Sciences Gifu University 1-1 Yanagido Gifu 501-1193 Japan

2. Department of Life Science and Chemistry Graduate School of Natural Science and Technology Gifu University 1-1 Yanagido Gifu 501-1193 Japan

3. Institute of Advanced Study Gifu University 1-1 Yanagido Gifu 501-1193 Japan

4. Institute of Advanced Study Center for One Medicine Innovative Translational Research (COMIT) Gifu University 1-1 Yanagido Gifu 501-1193 Japan

5. Institute for Glyco-core Research (iGCORE) Gifu University 1-1 Yanagido Gifu 501-1193 Japan

6. Institute of Nano-Life-Systems Institutes of Innovation for Future Society Nagoya University, Furo-cho, Chikusa-ku Nagoya 464-8603 Japan

Abstract

AbstractSupramolecular hydrogels can be obtained via self‐assembly of small molecules in aqueous environments. In this study, we describe the development of oxidation‐responsive supramolecular hydrogels comprising glucosamine derivatives with an aryl sulfide group. We demonstrate that hydrogen peroxide can induce a gel–sol transition through the oxidation of the sulfide group to the corresponding sulfoxide. Furthermore, we show that this oxidation responsiveness can be extended to photo‐responsiveness with the aid of a photosensitizer.

Publisher

Wiley

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