Engineered RebH Halogenase Variants Demonstrating a Specificity Switch from Tryptophan towards Novel Indole Compounds

Author:

Sana Barindra1,Ho Timothy2,Kannan Srinivasaraghavan3,Ke Ding1,Li Eunice H. Y.2,Seayad Jayasree2,Verma Chandra S.345,Duong Hung A.2,Ghadessy Farid J.1ORCID

Affiliation:

1. Disease Intervention Technology Laboratory Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 8 A Biomedical Grove, #06-04/05 Neuros/Immunos Singapore 138648 Singapore

2. Institute of Chemical and Engineering Sciences Agency for Science Technology And Research (A*STAR) 8 Biomedical Grove, Neuros, #07-01 Singapore 138665 Singapore

3. Bioinformatics Institute Agency for Science Technology And Research (A*STAR) 30 Biopolis Street, #07-01 Matrix Singapore 138671 Singapore

4. School of Biological Sciences Nanyang Technological University 60 Nanyang Drive Singapore 637551 Singapore

5. Department of Biological Sciences National University of Singapore 14 Science Drive 4 Singapore 117558 Singapore

Funder

Nanyang Technological University

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

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