Defluorination Capability of l ‐2‐Haloacid Dehalogenases in the HAD‐Like Hydrolase Superfamily Correlates with Active Site Compactness

Author:

Chan Peter W. Y.123,Chakrabarti Nilmadhab4,Ing Chris145,Halgas Ondrej1ORCID,To Terence K. W.36,Wälti Marielle37,Petit Alain‐Pierre89,Tran Christopher810,Savchenko Alexei811ORCID,Yakunin Alexander F.812ORCID,Edwards Elizabeth A.813ORCID,Pomès Régis14ORCID,Pai Emil F.1314ORCID

Affiliation:

1. Department of Biochemistry University of Toronto Toronto Ontario M5S 1A8 Canada

2. Present address: Zymeworks, Inc. 1385 West 8th Avenue Suite 540 Vancouver British Columbia V6H 3 V9 Canada

3. Princess Margaret Cancer Centre The Campbell Family Cancer Research Institute University Health Network Toronto Ontario M5G 1L7 Canada

4. Molecular Medicine Hospital for Sick Children Toronto Ontario M5G 1X8 Canada

5. Present address: ProteinQure, Inc. 119 Spadina Avenue suite 304 Toronto Ontario M5V 2L1 Canada

6. Present address: International Point of Care, Inc. 135 The West Mall, Unit 9 Toronto Ontario M9C 1C2 Canada

7. Present address: Laboratory of Chemical Physics National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD 20892–0510 USA

8. Department of Chemical Engineering and Applied Chemistry University of Toronto Toronto Ontario M5S 3E5 Canada

9. Present address: Biological Chemistry and Drug Discovery School of Life Sciences University of Dundee Dundee DD1 5EH UK

10. Present address: Ramboll Environment & Health 2400 Meadowpine Boulevard, Suite 100 Mississauga Ontario L5N 6S2 Canada

11. Present address: Department of Microbiology Immunology & Infectious Diseases University of Calgary Health Research Innovation Centre 3330 Hospital Drive NW Calgary Alberta T2N 4N1 Canada

12. Centre for Environmental Biotechnology School of Natural Sciences Bangor University Bangor Gwynedd LL57 2UW UK

13. Department of Cell & Systems Biology University of Toronto Toronto Ontario M5S 3G5 Canada

14. Department of Medical Biophysics University of Toronto Toronto Ontario M5G 1L7 Canada

Funder

Natural Sciences and Engineering Research Council of Canada

Government of Canada

Genome Canada

Ontario Genomics Institute

Basic Energy Sciences

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

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