Affiliation:
1. Department of Chemistry Kunming University 2 Puxing Road Kunming 650214 China
2. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany University of Chinese Academy of Sciences Chinese Academy of Sciences 132 Lanhei Road Kunming 650201 China
Abstract
AbstractLipopolysaccharides from the commensal gut‐associated microbiota are interesting biomolecules for the treatment of various inflammatory diseases. Different from pathogenic lipopolysaccharides, commensal lipopolysaccharides have distinct chemical structures and mediate beneficial homeostasis with the immune system of the host. However, the accessibility issues of homogenous and pure commensal lipopolysaccharides hampered the in‐depth studies of their functions. In this concept article, we highlight the recent synthesis of lipopolysaccharides from gut‐associated lymphoid‐tissue‐resident Alcaligenes faecalis and Bacteroides vulgatus, which hopes to inspire the more efforts devoting to these fantastic biomolecules.
Funder
National Natural Science Foundation of China
Yunnan Provincial Science and Technology Department
Subject
Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry