Affiliation:
1. Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN) Unidad de Genómica Avanzada Laboratorio Nacional de Genómica para la Biodiversidad (Langebio) Irapuato Guanajuato 36824 Mexico
2. CINVESTAV-IPN, Unidad Irapuato Departamento de Biotecnología y Bioquímica Irapuato Guanajuato 36824 Mexico
Abstract
AbstractCurrent cancer treatments damage healthy cells and tissues, causing short‐term and long‐term side effects. New treatments are desired that show greater selectivity toward cancer cells and evade the common mechanisms of multidrug resistance. Membranolytic anticancer peptides (mACPs) hold promise against cancer and multidrug resistance. Amphipathicity, hydrophobicity, and net charge of mACPs participate in their respective interactions with cell membranes and their overall inhibition of cancer cells. To support the design of cell‐line selective mACPs, we investigated the relationships that amino acid composition, physicochemical properties, sequence motifs, and sequence homology could have with their potency and selectivity towards several healthy and cancer cell lines. Sequence length and net charge are known to affect the selectivity of mACPs between cancer and healthy cell lines. Our study reveals that increasing the net charge or flexibility (i. e., small and aliphatic residues) influences their selectivity between cancer cell lines with comparable lipid compositions.
Funder
Consejo Nacional de Ciencia y Tecnología
Fundación Mexicana para la Salud
Subject
Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry