Jointly Depleting Glutathione Based on Self‐Assembled Nanomicelles for Enhancing Photodynamic Therapy-Reference-Cited by-同舟云学术

Jointly Depleting Glutathione Based on Self‐Assembled Nanomicelles for Enhancing Photodynamic Therapy

Published:2023-07-13 Issue:16 Volume:24 Page:
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Wu Jingxi¹,Shang Jingjing¹,An Jing¹,Chen Wenlong¹,Hong Gaobo¹,Hou Haoran¹,Zheng Wen‐Heng²,Song Fengling¹³^ORCID,Peng Xiaojun¹

Affiliation:

1. State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology Dalian 116024 China

2. Department of Interventional Therapy Cancer Hospital of Dalian University of Technology Liaoning Cancer Hospital and Institute Shenyang 110042 China

3. Institute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinary Science Shandong University Qingdao 266237 China

Abstract

AbstractPhotodynamic therapy (PDT) is one common ROS‐generating therapeutic method with high tumor selectivity and low side effects. But the GSH‐upregulation often alleviates its therapeutic efficiency. Here, we proposed a new strategy of jointly depleting GSH to enhance the therapeutic effect of PDT by preparing a nanomicelle by self‐assembly method from GSH‐activated photosensitizer DMT, curcumin, and amphiphilic polymer TPGS.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

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