Affiliation:
1. Key Laboratoryof Biocatalysis and Chiral Drug Synthesis of Guizhou Province Green Pharmaceuticals Engineering Research Center of Guizhou Province Zunyi Medical University 563000 Zunyi P. R. China
2. Key Laboratory of Basic Pharmacology of Ministry of Education Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical University 563000 Zunyi P. R. China
Abstract
AbstractOptically active epoxides play important roles in pharmaceutical, agricultural and fine chemical syntheses. There are many chiral medications with pharmacodynamic activity in nature that can be synthesized by chiral epoxides. In recent years, researchers have developed a variety of biocatalysts for the asymmetric epoxidation of alkenes, which use oxygen or hydrogen peroxide as eco‐friendly and low‐cost oxidants, to provide better chemo‐, regio‐ and stereoselectivity under moderate reaction conditions. In this paper, the advances, opportunities and challenges of the asymmetric epoxidation of unactive alkenes by biocatalyst are reviewed.
Funder
National Natural Science Foundation of China
Guizhou Science and Technology Department
Subject
Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry
Cited by
5 articles.
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