Affiliation:
1. Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education College of Life Sciences Jilin University Changchun 130023 P. R. China
2. State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun 130023 P. R. China
Abstract
AbstractWe report an efficient and eco‐friendly method for the Vitreoscilla hemoglobin (VHb)‐catalyzed synthesis of benzoxazoles in water at room temperature. tert‐Butyl hydroperoxide and 2,2,6,6‐tetramethyl‐1‐piperidinyloxy were used as oxidant and radical scavenger, respectively. A total of 27 functionally diverse benzoxazoles were prepared in moderate to high yields (62 %‐94 %) by the annulation reaction of phenols with amines in the presence of VHb in 1 h. Thus, this method is highly viable for practical applications. This work broadens the application of hemoglobin to organic synthesis.
Funder
Natural Science Foundation of Jilin Province
Subject
Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry