Affiliation:
1. Center for Nuclear Energy in Agriculture (CENA) University of São Paulo Avenida Centenário 303 Piracicaba 13416-000 Brazil
2. Institute of Pharmaceutical Sciences King's College London 150 Stamford Street London SE1 9NH UK
Abstract
AbstractMycosporine‐like amino acids (MAAs) are natural UV‐absorbing sunscreens that evolved in cyanobacteria and algae to palliate harmful effects from obligatory exposure to solar radiation. Multiple lines of evidence prove that in cyanobacteria all MAAs are derived from mycosporine‐glycine, which is typically modified by an ATP‐dependent ligase encoded by the genemysD. The function of the mysD ligase has been experimentally described but haphazardly named based solely upon sequence similarity to thed‐alanine‐d‐alanine ligase of bacterial peptidoglycan biosynthesis. Combining phylogeny and alpha‐fold tertiary protein structure prediction unambiguously distinguished mysD fromd‐alanine‐d‐alanine ligase. The renaming of mysD to mycosporine‐glycine‐amine ligase (MG‐amine ligase) using recognised enzymology rules of nomenclature is, therefore, proposed, and considers relaxed specificity for several different amino acid substrates. The evolutionary and ecological context of MG‐amine ligase catalysis merits wider appreciation especially when considering exploiting cyanobacteria for biotechnology, for example, producing mixtures of MAAs with enhanced optical or antioxidant properties.
Subject
Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry
Cited by
1 articles.
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