Affiliation:
1. School of Chemical Sciences University of Chinese Academy of Sciences Beijing 100049 China
2. School of Pharmaceutical Sciences Peking University Beijing 100191 China
Abstract
AbstractCovalent attachment of biologically active peptides/proteins with functional moieties is an effective strategy to control their biodistribution, pharmacokinetics, enzymatic digestion, and toxicity. This review focuses on the characteristics of different modification strategies and their effects on the biological activity of peptides/proteins and illustrates their relevant applications and potential.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Beijing Municipality
Fundamental Research Funds for the Central Universities
Subject
Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry
Cited by
3 articles.
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