Development of a novel low‐background noise blood loop model for testing blood‐contacting biomaterials and medical devices in fresh human blood

Author:

Cahalan Patrick1ORCID,Hegy Michael2,Cahalan Linda1,Curry Ben3,Ubl Samantha3,Jeffers Hannah4,Wolf Michael F.4

Affiliation:

1. Research Ension, Inc. Butler Pennsylvania USA

2. Whitaker College of Engineering Florida Gulf Coast University Fort Myers Florida USA

3. Medical Device Testing MLM Medical Labs Memphis Tennessee USA

4. Corporate Science and Technology Medtronic Minneapolis Minnesota USA

Funder

Center for Scientific Review

Publisher

Wiley

Subject

Biomedical Engineering,Biomaterials

Reference30 articles.

1. Blood‐materials interactions—20 years of frustration;Andrade JD;Trans Am Soc Artif Intern Organs,1981

2. PascheB SwedenborgJ HedinU OlssonP FrebeliuS LjungqvistA.Thrombogenicity of the vessel wall after single and repeated injury. Chapter II of PhD Thesis Non‐thrombogenic Properties of Artificial and Biological Surfaces Department of Experimental Surgery Karolinska Institute Stockholm Sweden 1989.

3. Thrombin inactivation on surfaces with covalently bonded heparin

4. Coating-techniques to improve the hemocompatibility of artificial devices used for extracorporeal circulation

5. Optimal heparin surface concentration and antithrombin binding capacity as evaluated with human non-anticoagulated bloodin vitro

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