Affiliation:
1. Tribology Research Institute, Key Laboratory for Advanced Technology of Materials of Ministry of Education Southwest Jiaotong University Chengdu China
2. State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization Pangang Group Research Institute Co., Ltd. Panzhihua China
3. R & D Center for High‐end Parts Chengdu Advanced Metal Materials Industry Technology Research Institute Co., Ltd. Chengdu China
Abstract
AbstractIn this study, multi‐scale triply periodic minimal surface (TPMS) porous scaffolds with uniform and radial gradient distribution on pore size were printed based on the selective laser melting technology, and the influences of porosity, pore size and radial pore size distribution on compression mechanical properties, cell behavior, and bone regeneration behavior were analyzed. The results showed that the compression performance of the uniform porous scaffolds with high porosity was similar to that of cancellous bone of pig tibia, and the gradient porous scaffolds have higher elastic modulus and compressive toughness. After 4 days of cell culture, cells were distributed on the surface of scaffolds mostly, and the number of adherent cells was higher on the small pore size porous scaffolds; After 7 days, the area and density of cell proliferation on the scaffolds were improved; After 14 days, the cells on the small pore size scaffolds tended to migrate to adjacent pores. Animal implantation experiments showed that collagen fiber osteoid was intermittent on scaffolds with high porosity and large pore size, which was not conducive to bone formation. The appropriate pore size and porosity of bone regeneration were 792 um and 83%, respectively, and the regenerative ability of gradient pore size was better than that of uniform pore size. Our study explains the rules of TPMS gyroid structure parameters on compression performance, cell response and bone regeneration, and provides a reference value for the design of bone repair scaffolds for clinical orthopedics.
Funder
Key Research and Development Program of Sichuan Province
Subject
Biomedical Engineering,Biomaterials
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