Silicon nanowire array overcomes chemotherapeutic resistance by inducing the differentiation of breast cancer stem cells

Author:

Wang Xiaotong1,Liu Sisi2,Zhang Wei1,Peng Haotong1,Zhang Miao1,Li Yaping3,Guo Qi1,Wang Wenjing1,Huang Na1,Liu LiYan4,Liu Dandan1ORCID

Affiliation:

1. College of Chemistry & Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding People's Republic of China

2. Cheng'an County Hospital of Traditional Chinese Medicine Handan People's Republic of China

3. College of Public Health Hebei University Baoding People's Republic of China

4. Medical Comprehensive Experimental Centrer Hebei University Baoding People's Republic of China

Abstract

AbstractCurrently, traditional cancer treatment strategies are greatly challenged by the existence of cancer stem cells (CSCs), which are root cause of chemotherapy resistance. Differentiation therapy presents a novel therapeutic strategy for CSC‐targeted therapy. However, there are very few studies on the induction of CSCs differentiation so far. Silicon nanowire array (SiNWA) with many unique properties is considered to be an excellent material for various applications ranging from biotechnology to biomedical applications. In this study, we report the SiNWA differentiates MCF‐7‐derived breast CSCs (BCSCs) into non‐CSCs by modulating the morphology of cells. In vitro, the differentiated BCSCs lose the stemness properties and thus become sensitive to chemotherapeutic drugs, eventually leading to the death of BCSCs. Therefore, this work suggests a potential approach for overcoming chemotherapeutic resistance.

Publisher

Wiley

Subject

Biomedical Engineering,Biomaterials

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