Affiliation:
1. State Key Laboratory of Separation Membranes and Membrane Processes, National Center for International Joint Research on Separation Membranes, School of Materials Science and Engineering Tiangong University Tianjin China
2. Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease Nankai University Affiliated Third Centre Hospital Tianjin China
Abstract
AbstractOxidative stress is highly prevalent in maintenance hemodialysis patients and increases the risk of cardiovascular morbidity and mortality. Silymarin (SM) is a natural compound extracted from plants, and has been shown to have pharmacological effects such as antioxidant, anti‐inflammatory, cytoprotective, and anti‐nephrotoxicity. SM‐modified polysulfone (PSF) hemodialysis membranes were prepared by an immersion‐precipitation phase transition method. The experimental results showed that the modified membranes effectively scavenged free radicals, significantly inhibited lipid peroxidation, and had good antioxidant stability (60 days). The PSF/SM antioxidant membranes (H‐3) had no pro‐inflammatory effect, which was confirmed by the result of anti‐M1 macrophage polarization. Furthermore, the hemolysis rate (2%), blood cell deformation (3.7%), and inhibition of erythrocyte and platelet adhesion were improved by the SM‐modified PSF membranes. All the results suggest that PSF/SM blended hollow fiber membranes are promising for application in hemodialysis membranes to improve oxidative stress status and reduce inflammation and complications in patients.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Tianjin City
Natural Science Foundation of Tianjin Municipal Science and Technology Commission
Subject
Biomedical Engineering,Biomaterials
Cited by
1 articles.
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