Affiliation:
1. Department of Chemistry and Biomolecular Science Clarkson University Potsdam New York 13699 USA
2. Department of Chemistry The Pennsylvania State University University Park Pennsylvania 16802 USA
3. Department of Surgery The Pennsylvania State University, College of Medicine Hershey Pennsylvania 17033 USA
4. Department of Biomedical Engineering The Pennsylvania State University Hershey Pennsylvania 17033 USA
Abstract
AbstractBiomaterial‐associated microbial infection is one of the most frequent and severe complications associated with the use of biomaterials in medical devices. In previous studies, we developed new fluorinated polyphosphazenes, poly[bis(octafluoropentoxy) phosphazene] (OFP) and crosslinkable OFP (X‐OFP), and demonstrated the inhibition of bacterial adhesion and biofilm formation, thereby controlling microbial infection. In this study, two additional fluorinated polyphosphazenes (PPs, defined as LS02 and LS03) with fluorophenoxy‐substituted side groups, 4‐fluorophenoxy and 4‐(trifluoromethyl)phenoxy, respectively, based on X‐OFP general structure, were synthesized and applied as coatings on stainless steel. The linkage of fluorophenoxy groups to the P‐N backbone of PPs was found to increase the surface stiffness and significantly reduced Staphylococcus bacterial adhesion and inhibited biofilm formation. It also significantly reduced microbial infection compared to OFP, our prior X‐OFPs or poly[bis(trifluoroethoxy) phosphazene] (TFE). The biofilm experiments show that the newly synthesized PPs LS02 and LS03 are biofilm free up to 28 days. Plasma coagulation and platelet adhesion/activation experiments also demonstrated that new PPs containing fluorophenoxy side groups are hemocompatible. The development of new crosslinkable fluorinated PPs containing fluorophenoxy‐substituted side groups provides a new generation of polyphosphazene materials for medical devices with improved resistance to microbial infections and thrombosis formation.
Funder
National Heart, Lung, and Blood Institute
National Institute of Allergy and Infectious Diseases
Subject
Biomedical Engineering,Biomaterials
Cited by
3 articles.
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