Affiliation:
1. Matériaux et Santé, UFR de pharmacie Université Paris‐Saclay Orsay France
2. Vygon Ecouen France
3. Department of Pharmacy Assistance Publique‐Hôpitaux de Paris, Groupe hospitalier Henri Mondor Créteil France
Abstract
AbstractThis article investigates the impact of the interactions between polyurethane central venous catheters and solutions containing excipients used in cisplatin and paclitaxel formulations. Changes to the properties of catheters and the leaching of catheter additives into the infused solutions were studied while these solutions were infused cyclically for several months. Chemotherapy treatment was mimicked in vitro in compliance with hospital practices. The treatment cycle was repeated 10 times, using solutions containing only the excipients. After 10 treatment cycles, no physical or chemical degradation of the catheter was observed. Mechanical performances were stable, but surface modifications occurred, causing the surface to become more hydrophobic. A loss in polyurethane antioxidant amount was observed in part due to a leaching phenomenon.
Funder
Association Nationale de la Recherche et de la Technologie
Subject
Biomedical Engineering,Biomaterials