Affiliation:
1. Department of Otolaryngology Taihe Hospital, Hubei University of Medicine Shiyan China
2. Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Shenzhen China
3. Department of Pathology School of Basic Medical Science, Hubei University of Medicine Shiyan China
Abstract
AbstractFolate receptor 1 (FOLR1) is overexpressed in numerous epithelial malignancies; however, its role in laryngeal squamous cell carcinoma (LSCC) remains unclear. In the present study, we demonstrated that FOLR1 messenger RNA and protein expression levels were higher in LSCC tissues than in the adjacent normal tissues. Additionally, FOLR1 promoted the proliferation and migration of LSCC cells, whereas small interfering RNA‐mediated knockdown of β‐catenin abolished these effects. Moreover, FOLR1 stabilizes β‐catenin by inhibiting its ubiquitination and degradation. Furthermore, blocking the interaction between epidermal growth factor receptor (EGFR) and the EGFR/AKT/glycogen synthase (GSK)3β signaling axis both abolished FOLR1's effects on the expression and nuclear aggregation of β‐catenin. In summary, our work reveals a novel mode in which FOLR1 promotes the proliferation and migration of LSCC by enhancing the stability and nuclear translocation of β‐catenin through the EGFR/AKT/GSK3β axis.
Subject
Cancer Research,Molecular Biology